Composition
Each capsule contains Chloroquine phosphate 250mg:
Description
Capquin is an antimalarial product belonging to the group of 4-aminoquinoline. It is a rapidly acting schizonticide, well tolerated and safe. The product is packed in capsules to mask the bitter taste of the product.
Pharmacology
Mircobiology: Capquin has been found to be highly active against the erythrocytic forms of Plasmodium vivax and malariae and most strains of Plasmodium falciparum. The precise mechanism of action of the drug is unknown. While the drug can inhibit certain enzymes, its effect is believed to result from its interaction with DNA. It appears that it acts against the blood schizonts by influencing haemoglobin digestion by the malarial parasites. Capquin also possesses amoebicidal activity comparable to that of emetine. Pharmacokinetics (Absorption): Rapid peak blood levels are achieved in 1 to 2 hours Distribution: It is widely distributed throughout the body and present in high concentrations in the liver, kidneys, lungs and crosses the placenta and appears in breast milk Protein binding: About 50 to 65% Excretion: Approximately 70% of a dose is excreted unchanged in the urine, and 10% in faeces. Acidification of the urine increases elimination of the drug. Small amounts of the drug may be present in the urine months following discontinuation of therapy.
